We are seeking a highly motivated individual to join our Protein Design team and help develop Antibody Cage (AbC) therapeutics towards the clinic. The candidate should have a strong background in computational protein design, as well as experience with implementing machine learning methods to integrate desirable biophysical/biological properties into new designs. Working closely with our in-house team of drug development experts and leveraging our high-throughput testing pipeline, the candidate will help design the next generation of AbC therapeutics, synthesize our experimental results, and help build our strategies to engineer drug-like characteristics and improve our success rate over time.

If you are excited to be part of a team that’s transforming the future of biologics, we want to hear from you. Please submit your resume and a cover letter detailing your relevant experience and what inspires you about Archon Biosciences. Let’s shape the future of medicine together.

You may reach us at contact@archon.bio or click the button below.

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Key Responsibilities:
• Design and develop novel AbC therapeutics using a mixture of cutting-edge protein design and modeling methods, working closely with the Archon Protein Production team and drug development experts.
• Build protein libraries for hit identification, development candidate selection, and data set generation. Develop design methods to integrate key desirable properties to engineer drug-like characteristics into AbCs.
• Effectively store experimental data to thoughtfully and systematically interrogate key biophysical and biological properties to develop understanding of those most important for target behavior.
• Develop machine learning-based design methods and apply towards the design and optimization of AbC designs. Document new design/training methods and maintain meticulous experimental records.
• Collaborate with experimental biologists and translational scientists to refine AbC designs and strategies, and identify development candidates.
• Communicate results effectively to internal teams and external stakeholders, contributing to publications and presentations.
• Assist management team with preparing data reports for board meetings, data reports, pharma and investor due diligence.
• And other responsibilities as assigned by manager.
Required Qualifications:
• PhD or postdoc in Computational Biology, Data Science, Biochemistry, Structural Biology, or related field with 5+ years of industry experience, or MS with 8+ years of experience.
• Expertise in protein design, data science, bioinformatics, machine learning, deep learning, neural networks and generative AI. Softwares including RFdiffusion, proteinMPNN, Alphafold, and Rosetta.
• Familiar with design parametrization (sequence and/or structure), protein language models and embedding, machine learning concepts and data sets required to generate high-quality AI/ML models.
• Experience in high-throughput wet lab workflows for protein purification and biophysical characterization of designed proteins and nanomaterials.
• Experience and knowledge in the protein biologics space.
• Proficiency in software development and scripting (Python, C++, Bash, etc.).
• Experience with data analysis workflows (e.g. Jupyter Notebook).
• Familiarity with AWS or other cloud-based platforms.
• Knowledge of cloud data storage best practices (data lakes, data warehouses etc.).
• Experience with automation of compute workflows on the cloud (e.g. AWS, Papermill).
• Demonstrated ability to solve complex scientific challenges and advance R&D programs.
• Stay up to date with literature, exploring novel computational methods to test, and identifying new ways they can be applied to develop therapeutics.
• Work well with people of diverse backgrounds and experiences, working together in a team environment to bring innovative solutions into practice.
Preferred Qualifications:
• Experience with novel therapeutic modalities and protein or antibody-based biologics.
• Proficiency in data management tools such as Benchling and experience with lab automation/robotics.
• Developability and formulation experience, and familiarity with CMC process assessments.
• Strong leadership and mentorship capabilities.
At Archon, you will have the chance to work on science that is truly transformative.
At Archon, we offer:
• A mission-driven environment where your work directly contributes to improving patient outcomes.
• Opportunities for professional growth and development within a rapidly expanding company.
• A collaborative and inclusive culture that values innovation and scientific rigor.
• Competitive compensation, including a base salary ($140,000–$200,000), equity opportunities, and comprehensive benefits.
• Flexible PTO, paid parental leave, and other employee-centric policies designed to support work-life balance.
Who We Are:
At Archon Biosciences, we are redefining what’s possible in drug development. Our groundbreaking Antibody Cage (AbC) platform—spun out of work spearheaded by Institute for Protein Design faculty out of Dr. David Baker's Nobel Prize-winning lab—combines antibodies with computationally designed proteins to create novel nanostructures that target previously undruggable diseases. AbCs, A revolutionary class of computationally designed biologics are engineered to unlock challenging pathways and better treat disease.
Headquartered in Seattle, WA, Archon is a fast-growing biotech company operating at the intersection of generative protein design and therapeutic innovation. We recently emerged from stealth with $20 million in seed financing led by Madrona Ventures with participation from a group of extraordinary investors. With this capital, we have assembled a team of world-class scientists and drug developers to develop the AbC technology and select development candidates set for IND. We are passionate about pushing the boundaries of medicine to improve patient outcomes.
Our Culture:
Innovation, collaboration, integrity, and impact are at the heart of everything we do at Archon. We value diversity in perspective and foster an environment where curiosity and creativity thrive. Our team is united by a shared drive to achieve groundbreaking results and make a meaningful difference in the lives of patients. We want good people that do great work. If you are looking for a dynamic, fast-paced environment where your contributions matter and will have impact, Archon is the place for you.

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